Preview the Week 8 matchup between the Houston Texans and San Francisco 49ers with predictions, odds, over/under, spread, betting lines and more.

The San Francisco 49ers have a chance to raise their record to a surprising 6-2 going up against a struggling Texans team, but can the Niners get going against Houston's tough defense?

Kickoff from NRG Stadium is set for 1 p.m. ET, and the Texans are 1.5-point favorites, according to the latest 49ers vs. Texans odds. The over/under for total points scored is 42. Before you make any Texans vs. 49ers picks, make sure to check out what the SportsLine Projection Model has to say.

Preview the San Francisco 49ers' NFL Week 8 matchup with the Texans, including live stream, TV channel, odds, and game information.

A week after the San Francisco 49ers improbably dominated the NFL's second-ranked offense, they'll be given a far less formidable test when they visit the Houston Texans.

The Houston Texans will be without Nico Collins for Sunday's game against the San Francisco 49ers. Jayden Higgins and Jaylin Noel must step up.

The Houston Texans receive unfortunate injury updates for the San Francisco 49ers game regarding Nico Collins and Christian Kirk.

Despite being one of the most banged-up teams in the NFL, San Francisco sits tied atop the NFC West with the Seahawks and the Rams. A big reason is the play of Jones under center. The veteran has resurrected his career in leading San Francisco forward despite injuries to a laundry list of players including Brock Purdy, Brandon Aiyuk, and Nick Bosa.