Patients with non-small cell lung cancer who have mutations in the KRAS gene should respond well to the antifolate class of drugs, according to results of a recent study comparing human lung cancer ...

Pharmacokinetic/pharmacodynamic assessment of a proposed biosimilar MSB11455 versus the currently licensed pegfilgrastim: A randomized, double-blind trial. This is an ...

Antifolates, folate analogs that inhibit vitamin B₉ (folie acid)-using cellular enzymes, have been used over several decades for the treatment of cancer and inflammatory diseases. Cellular uptake of ...

Chemists have produced detailed descriptions of the structure and molecular properties of human folate receptor proteins, a key development for designing new drugs that can target cancer and ...

Non-small cell lung cancer patients, having mutations in the KRAS gene should respond well to the antifolate class of drugs, recent study shows. The results were of a recent study conducted by ...

Testing patients with non-small cell lung cancer for both mutations and amplifications of the KRAS gene prior to therapy may help to predict response to treatment with antifolates, according to the ...

Experimental antibiotics that kill a common and a deadly bacteria called MRSA (Methicillin Resistant Staphylococcus aureus) which causes skin, lung and heart infections were developed by a research ...

Antifolates have a crucial role in the treatment of various cancers by inhibiting key enzymes in purine and thymidylate biosynthesis. However, the frequent emergence of inherent and acquired ...