Spider-Man's #1 villain served up his first defeat 63 years ago.

First, on choosing Brainiac and Doctor Octopus as the villains for his Superman/Spider-Man story through DC. "Blind panic because I had written a plot and everybody approved it and it was all awesome ...

The Sinister Six is one of the best Spider-Man villains, and they have been involved in several great storylines.

When it comes to supervillains, Doctor Octopus stands apart from the common clay. While motivated by revenge and profit, Doc Ock occasionally shows some signs of humanity amid his madness. Such a sign ...

Luke Cage, Mayor of New York has to deal with the fact that Doctor Octopus has been appointed by Senator Frask, the new Presidential Advisor Of Symbiote Affairs and in charge of the governmental body ...

Spider-Man has taken some severe beatings over the years and here are five times he was at the brink of death.