The mechanism of skeletal muscle contraction is a process that relies on calcium signaling. However, the physiological role of calcium-induced calcium release (CICR) through the ryanodine receptor ...

The contraction of smooth muscle is an essential process underpinning diverse physiological functions ranging from gastrointestinal motility to vascular regulation. At its core, smooth muscle ...

Researchers engineered mice with a mutation (E3896A) in the RyR1 calcium-binding site, eliminating calcium-induced calcium release (CICR) without affecting depolarization-induced calcium release. The ...

Genetic inhibition of RyR1-mediated calcium-induced calcium release reveals its minimal role in skeletal muscle contraction and its critical contribution to malignant hyperthermia risk You are free to ...

Scientists discover that muscles repair themselves by moving thousands of internal nuclei, a rapid process that is key after ...

A new role of calcium in the development of muscles has been reported by two RIKEN biologists. Stress is generally damaging ...

In adults over 65, the prevalence of low bone mineral density (LBMD), including osteopenia and osteoporosis, rises steeply, with women disproportionately affected. About 60% of women and nearly 25% of ...

Muscle contraction is the tightening, shortening, or lengthening of muscles when you do some activity. It can happen when you hold or pick up something, or when you stretch or exercise with weights.

Myotonic dystrophy type 1 (DM1) is the most common form of adult-onset muscular dystrophy, affecting about 1 in 8,000 people.