Aurélien Vigneron, Michelle B. O’Neill, Brian L. Weiss, Amy F. Savage, Olivia C. Campbell, Shaden Kamhawi, Jesus G. Valenzuela, Serap Aksoy Proceedings of the National Academy of Sciences of the ...

The manuscript concerns a fundamental and controversial question in Trypanosoma brucei biology and the parasite life cycle, providing further evidence that slender bloodstream forms can indeed infect ...

Bloodstream forms of Trypanosoma brucei lack cytochromes and are, therefore, insensitive to cyanide. Azide is a toxic anion that bears chemical and biological properties in common with cyanide and may ...

Trypanosoma are a nasty class of single-celled parasites that cause serious, even fatal, diseases in human and animals. Two species cause sleeping sickness, a disease that threatens all of ...

Trypanosoma brucei, the causative agent of African sleeping sickness, represents a paradigm of parasite evolution and immune evasion. Its ability to periodically change its variant surface ...

If left untreated, African Sleeping Sickness can causes meningoencephalitis, coma, and death. The disease is spread through tsetse flies that feed on infected hosts. In 2015, 84 percent of Trypanosoma ...

Trypanosoma brucei infection induces fat breakdown, but this strategy benefits the host. To uncover how the parasite induces fat loss, the researchers used wildtype and knockout mice that lacked ...

A new study led by researchers at the Johns Hopkins Bloomberg School of Public Health sheds light on how the blood-borne parasite that causes African sleeping sickness in humans and related diseases ...

Infections can present with many different symptoms, and one common symptom is wasting, which involves the loss of fat and in extreme cases lean muscle as well. Researchers in the lab of Salk ...

African Sleeping Sickness, also known as Human African Trypanosomiasis, is a tropical disease that evolves through distinct clinical stages. It ultimately results in meningoencephalitis, coma, and ...