The San Francisco 49ers were hoping their rookies would be ready to pick up the slack after injuries to so many veteran players. Those hopes were dashed in Houston.

Houston Texans cornerback Kamari Lassiter, right, intercepts a pass intended for San Francisco 49ers wide receiver Jauan Jennings during the second half of an NFL football game Sunday, Oct. 26, 2025, in Houston. Sunday’s loss to the Texans was the latest chapter in a season to forget for 49ers receiver Jauan Jennings.

We always knew the San Franciscio 49ers 2025 rookie class going to have a big say in what the outcome of the season would be. While the team got off to a hot start, and the rookie class has had some highs, the lows of the class also have shown in what could be a sign that the 49ers season does not have a high ceiling.

The San Francisco 49ers have been struggling with injuries all season, and it finally caught up with them. On Sunday, they lost 26-15 to the Houston Texans.

NFL Week 9 odds, picks, predictions, TV channel, streaming information for the Sunday football game between San Francisco 49ers and New York Giants.

The 49ers still aren’t sure if Brock Purdy will play against Giants, but surface at MetLife Stadium will not be a factor.

Purdy was on the 49ers’ sideline in a road game for the first time since re-aggravating his toe injury against the Jaguars. He did not travel to Los Angeles on Oct. 2, and didn't travel to Tampa on Oct. 11. While he was on the sideline for last week’s game against Atlanta, that was a home game.

San Francisco 49ers head coach Kyle Shanahan provided injury updates on Monday afternoon. The team plans to open the practice window for guard Ben Bartch, who has not played since the first quarter of Week 2 after suffering a high-ankle sprain.