The San Francisco 49ers have not been healthy this season, and with Fred Warner and Nick Bosa out for the season, they will ...

Head coach Kyle Shanahan on Friday told reporters wide receiver Brandon Aiyuk is making progress toward a return that could ...

Here's the latest on San Francisco 49ers star wide receiver Brandon Aiyuk following a knee injury last season.

Those who were declared out Sunday were quarterback Brock Purdy (toe), center Jake Brendel (hamstring), edge rusher Bryce ...

Kyle Shanahan’s San Francisco 49ers lead the NFC West, even without one of Brock Purdy and Mac Jones’ key weapons on the ...

He’s on pace to finish the season with 1,129 rushing yards and seven scores and 129 catches for 1,253 yards and seven ...

If the 49ers win Sunday in Houston, they’ll match their overall win total from last season and they’ll be alone atop the NFC ...

A week after the San Francisco 49ers improbably dominated the NFL's second-ranked offense, they'll be given a far less ...

The San Francisco 49ers take on the Houston Texans at 10 a.m. PT on Sunday, Oct. 26 at NRG Stadium in Houston.

Explore why 49ers' Christian McCaffrey is considered the most disappointing player this season despite leading the NFL in ...

There haven't been many NFL teams this season who have surpassed their early expectations quite like the Los Angeles Rams ...