In a recent interview with Entertainment Weekly, Bruckheimer revealed that he has spoken to Depp about coming back for the sixth Pirates film, and the actor is at least open to the idea. The famous Producer explained: If he likes the way the part's written,

For years, it looked like Johnny Depp ’s Captain Jack Sparrow had sailed off for good. After Disney cut ties with the actor in 2018, Depp famously said during his 2022 defamation trial with Amber Heard that he wouldn’t return “for $300 million and a million alpacas.

A female-led Pirates of the Caribbean 6 starring Margot Robbie has been discussed. Though Robbie later said the film was no longer in development, Bruckheimer has still sometimes mentioned it as a possibility. There were also rumors of Disney hoping to cast Karen Gillan in a sixth film.