On Wednesday, Mitchell was added to the team’s growing list of injuries. The Cavaliers announced their official injury report to the NBA ahead of Wednesday’s game against the Boston Celtics, and Mitchell’s name appeared just hours before tipoff. He was listed as questionable with left hamstring tightness.

Donovan Mitchell scored 35 points in just 29 minutes, and the Cleveland Cavaliers beat the Detroit Pistons 116-95 on Monday night for their third straight victory.

During the Cleveland Cavaliers ' season opener at Madison Square Garden, guard Lonzo Ball hit big man Larry Nance Jr. with a perfectly placed lob pass. Nance threw it down, punctuating a 10-0 Cavs run and prompting sidelined star Darius Garland to rise from his seat and let out a scream that was clearly audible on the ESPN broadcast.

Both the Boston Celtics and Cleveland Cavaliers may be without multiple key players in Wednesday night's matchup.

The Cleveland Cavaliers’ 2025-2026 season starts up officially Wednesday but it’s not until the weekend that hometown fans can watch them in action in person. While the roster is made up of many of the same players you’ve come to know and love over the past few seasons, many questions remain about how this all plays out this time around.

Retail sales at all outlets are up 34.4% over last year, part of a steady climb since Donovan Mitchell’s arrival and the team’s push into lifestyle and collaborative merchandise. That figure includes all Rock Entertainment Group (REG) properties — the Cavaliers, Cleveland Monsters, Cleveland Charge and the WNBA team scheduled to debut in 2028 .