The San Francisco 49ers are used to playing shorthanded, but this week they will also face a foe that is coming in without their best player on offense. Nico Collins is going to miss the Houston Texans' Week 8 matchup with the 49ers due to a concussion.

No positive update has been provided on Ricky Pearsall.

The Texans can't afford to lose too many more games if they want to repeat as AFC South champs, especially with the Indianapolis Colts off to a stellar 6-1 start.

Christian McCaffrey will lead the San Francisco 49ers (5-2) into their battle versus the Houston Texans (2-4) at NRG Stadium, on Sunday at 1 p.m. ET.

The Texans' defense dominated the Seahawks and made the game closer than expected.

Quarterback Brock Purdy will miss his fourth straight game and sixth in the past seven weeks for the San Francisco 49ers with a toe injury. Coach Kyle Shanahan said Friday (Saturday in Manila) that Purdy was ruled out this week against the Houston Texans but will travel for the game as his condition has improved.

Coach Kyle Shanahan said Purdy has been progressing, albeit slowly, and the uncertain nature of the toe injury has made nailing down a return date more difficult.