Case Study 187: Cushing’s Disease Cushing’s disease is a specific form of Cushing’s syndrome caused by a pituitary adenoma that secretes excess adrenocorticotropic hormone (ACTH) — driving the adrenal glands to produce excess cortisol. 📊 Facts & Figures: • Cushing’s disease accounts for 60–70% of endogenous Cushing’s syndrome cases. • It is 3–5 times more common in women, especially between the ages of 20–40. • Average tumor size is 5 mm, often invisible on MRI — making diagnosis challenging. •