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Serotonin syndrome is a potentially serious medication reaction caused by excess serotonin in the nervous system. It most often happens after a dose increase or medication combination, not from a single drug alone. Common triggers include: • SSRIs/SNRIs • Triptans (migraine meds) • Antiemetics (like ondansetron) • Certain pain meds • OTC or “natural” mood supplements (5-HTP, St. John’s wort) Key symptoms to know: • Agitation, restlessness, confusion • Rapid heart rate, sweating, fever • Diarrhea
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