The Broad Institute is a non-profit research organization that convenes academic investigators and professional scientists from around Boston and around the world, removing roadblocks so that scientists can work together to solve important problems and propel the understanding and treatment of disease. Hear Broad scientists share what makes the Broad Institute special: | Broad Institute of MIT and Harvard
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The Broad Institute is a non-profit research organization that conven…
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The shapes of cell nuclei can help doctors diagnose diseases ranging from cancers to blood disorders. A new technique called expansion in situ genome sequencing (ExIGS) from Ajay Labade, Zachary Chiang, Caroline Comenho, Fei Chen, Jason Buenrostro, and others is now expanding the amount of information researchers can extract from individual nuclei. ExIGS — a combination of in situ sequencing and expansion microscopy — allows scientists to sequence DNA and map its location relative to nuclear pro
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A new method from the lab of Xiao Wang is the first large-scale approach to track many mRNAs at once, over both space and time in individual cells. Maps generated by the method, known as TEMPOmap, can help uncover new principles of gene regulation and explore how RNA life cycle patterns influence the function of various cell types in health and disease. “Biology is, by nature, a dynamic process,” said co-first author Jingyi (Rena) Ren. “By following these RNAs, we can help answer some fascinatin
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A new method from the lab of Xiao Wang is the first large-scale appro…
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